化合物 T14703_化工百科

中文名	Karenitecin
英文名	Karenitecin
别名	化合物 T14703
英文别名	DB 172 BNP 1350 MCC 12824 Cositecan Karenitecin
CAS	203923-89-1
化学式	C25H28N2O4Si
分子量	448.59
密度	1.29±0.1 g/cm3(Predicted)
沸点	727.2±60.0 °C(Predicted)
溶解度	溶于DMSO，不溶于水
酸度系数	11.27±0.20(Predicted)
存储条件	2-8℃
MDL号	MFCD09833216
体外研究	Karenitecin is a topoisomerase I inhibitor, with potent anti-cancer activity. Karenitecin inhibits cell growth of A253 cells with IC 10 , IC 50 , and IC 90 values of 0.01, 0.07, and 0.7 μM after 2 h treatment. Karenitecin induces DNA damage (0.01, 0.07, and 0.7 μM), and increases cyclin E and cdk2 protein expression in A253 cells (0.07, and 0.7 μM). Karenitecin markedly enhances the cyclin B/cdc2-associated kinase activity at low concentration, but slightly suppresses this kinase activity at higher concentration. Karenitecin inhibits several human colon cancer cell lines such as COLO205, COLO320, LS174T, SW1398 and WiDr cells, with IC 50 s of 2.4 nM, 1.5 nM, 1.6 nM, 2.9 nM, and 3.2 nM, respectively.
体内研究	Karenitecin shows maximum growth inhibition of 61% on COLO320 cells and 54% on COLO205 colon cancer cells via i.p. administration of 1 mg/kg in mice. Karenitecin (1.0 mg/kg daily × 5 i.p.) significantly suppresses growth inhibition both in the parental Pgp-negative xenografts and in the Pgp-positive xenografts.

化合物 T14703 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.229 ml	11.146 ml	22.292 ml
5 mM	0.446 ml	2.229 ml	4.458 ml
10 mM	0.223 ml	1.115 ml	2.229 ml
5 mM	0.045 ml	0.223 ml	0.446 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: Karenitecin 去供应商网站查看询盘
CAS: 203923-89-1
产地: 中国上海
包装: 10mg
规格: 98%
价格: 8498.00
库存: 现货
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产品描述: 中文名：Karenitecin 英文名:Karenitecin CAS:203923-89-1 规格:98% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: Karenitecin 去供应商网站查看询盘
CAS: 203923-89-1
产地: 上海
规格: K911171
价格: 5mg-5610
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
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上海源叶生物科技有限公司

产品名: Karenitecin 去供应商网站查看询盘
CAS: 203923-89-1
产地: 上海
规格: 98%
价格: 5mg 5500,10mg 8500
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403